Objective
The aim of the project is to test the hypothesis that, in chronic arthritis, a polarised Thl response drives articular disease and is followed by a protective Th2 response that mediates extra-articular disease. In order to do so, a chronic relapsing form of collagen-induced arthritis in mice will be developed that more closely resembles rheumatoid arthritis than the model induced with bovine type II collagen (CII), which is a self-limiting disease. DBA/1 mice will be immunised with mouse CII, which is known to induce chronic arthritis. Alternatively (and more conveniently), mice will be immunised with a DNA plasmid encoding mouse CII.
Chronic relapsing disease will be described in detail: clinical course, extra-articular disease, joint histology, phenotype of synovial cells and cytokine production by the synovium and lymph nodes. In addition, Th 1 or Th2 responses will be manipulated with cytokines or antibodies, such as IL-4, IL-12 or anti-IL-12.
A chronic murine model of arthritis will provide a highly valuable tool for studying pathogenesis and therapy of rheumatoid arthritis.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine rheumatology
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences histology
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
W6 7LH London
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.