Objective
Excessive NO causes tissue damage in diseases of unmet medical need such as stroke, arthritis and diabetes. Induction of Type II NOS contributes importantly to cytotoxicity and bystander damage in these pathological states. Current inhibitors are mainly arginine mimics and show limited selectivity for type II NOS over the constitutive Type I and Type III isoforms and have side effects. Synthesis of inhibitors of the binding of tetrahydrobiopterin, a cofactor requires by the enzyme, by means of non-pterin moieties which also bind haem to provide a possibly unique "selectivity signature" for NOS is proposed as a novel approach to selective NOS inhibition. Suitable leads are available in 7-nitroindazole and in phenylimidazole isomers, and data for pterins suggest that the tetrahydrobiopterin binding sites of the NOS isoforms may be distinguishable. In addition, because of its high level of expression, Type II NOS may be particularly susceptible to this form of inhibition.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine rheumatology
- medical and health sciences clinical medicine endocrinology diabetes
- medical and health sciences basic medicine neurology stroke
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
TW8 9EP Brentford
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.