Objective
Cell-cell interaction, and particularly cell-cell adhesion and gap junctional communication, appear to play an important role during embryo development and tissue formation. In addition, at least in the case of desmosomal- and caherin-based cell adhesion, these processes may have a decisive role in the formation of carcinomas, tumors and metastases. Both in mammals and lower vertebrates, desmosomal structures and gap junctions have been described in close proximity in the ovarian follicle, although their molecular composition and specific physiological role during follicle development remains to be elucidated. Recent experiments using specific molecular approaches have sugested that cell adhesion may require signaling trough gap junctional pathways, and thus both cell contact structures appear to be interdependent. The aim of the present project is to develop new information on the molecular composition and specific cellular localization of the desmosomal proteins in the vertebrate ovarian follicle. In addition, as a novel approach, the specific interactions between desmosomal and gap junctions, and their possible significance during follicle development, will be investigated using specific antisera and transfection of cDNAs encoding stable dominant-negative inhibitors.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences cell biology
- natural sciences biological sciences zoology mammalogy
- medical and health sciences clinical medicine embryology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
69120 Heidelberg
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.