Objective
The principal aim of this project is to determine factors that regulate the establishment of the spatially restricted pattern of expression of Hox genes in the developing vertebrate nervous system. Hox genes are true homologues of the homeotic genes first identified in Drosophila and have a central role in axial patterning in all metazoans.
Spatial enhancers will be characterised in transgenic mice using a lacZ reporter gene. Deletion and sequence analysis will determine the minimal elements required for the spatial expression of the gene under study, and this will allow us to search for candidate factors that are upstream in the regulatory cascade that leads to pattern formation in the brain. Comparison of the enhancer with similar elements from other Hox genes expressed in overlapping patterns (paralogues) and with homologous genes from other vertebrates (chick and puffer-fish) will help to determine how far these upstream regulatory networks have been conserved in evolution.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
NW7 1AA London
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.