Objective
Genetic studies on C. elegans have identified genes for several nicotinic acetylcholine receptor subunits and functionally associated proteins. Analysis of viable mutants allows correlations of specific nAChR structural alterations to changes in behaviour. Molecular cloning and functional expression of C. elegans nAChR subunits permit the study of the organism's novel pharmacology and physiology. This also provides insights into the mode of action of cholinergic anthelmintic drugs, and may facilitate rational design of novel, safer animal health and pharmaceutical products. Use of the green fluorescent protein reporter gene will allow the study of the cellular localization and developmental pattern of nAChR subunit expression in an animal. Such data will be obtained in the only nervous system for which the complete cell lineage and wiring diagram is known. These studies will be pursued during the period in which the C. elegans genome sequence is completed enabling an enhanced understanding of cholinergic synaptic signalling and its regulation throughout development.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine physiology
- natural sciences biological sciences genetics genomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
CB2 3EJ Cambridge
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.