Objective
Epithelial cells display polarized distributions of proteins and lipids on the cellular surface. Apical and basolateral sorting, initiated in the TGN, leads to cellular asymmetry by recognition of sorting signals by known and unknown receptors. Isolation of the protein constituents from TGN derived transport vesicles have led to the identification of novel proteins, including VIP36; a protein homologous with mammalian and leguminous lectins, raising the possibility that it may recognize oligosaccharide ligands and be involved in apical sorting. These studies seek to identify the natural oligomeric state of VIP36 and characterize its natural carbohydrate ligands. Additionally, recycling of VIP36 from the cell surface to the TGN will be investigated using both site specific gene mutations and biochemical approaches. Further mutations or anti-sense nucleotides will be used to mistarget or block expression of VIP36, respectively. The effects of these perturbations on the sorting of natural VIP36 ligands will be analyzed.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences biochemistry biomolecules lipids
- natural sciences biological sciences genetics mutation
- natural sciences biological sciences biochemistry biomolecules carbohydrates
- natural sciences biological sciences genetics nucleotides
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
69117 Heidelberg
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.