Objective
We propose to study molecular mechanisms underlying T cell tolerance induction and its breakdown by bacterial superantigens. We are using transgenic mice (F5) expressing a T Cell Receptor (TCR) specific for the nucleoprotein (NP) of the influenza virus crossed to mice expressing ubiquitously the NP antigen. F5/NP doubly transgenic mice in the RAG1 / background develop only anergic T cells. Those can be reactivated and acquire cytotoxic effector functionin vivo by administration of the bacterial superantigen Staphylococcal Enterotoxin A (SEA). We will a) attempt to define conditions at which reactivated T cells can lead to autoimmunity in these mice; b) study the role of TNFx in T cell tolerance and activation in F5 and F5/NP mice by crossing them to TNFx / mice and challenge them with antigenic NP peptide and SEA; c) identify and characterise genes involved in T cell tolerance using an improved version of the mRNA differential display technology. Our studies will improve the understanding of detrimental immune responses and could help in the development of strategies for clinical interventions in humans. Training content (objective, benefit and expected impact)
Our goal is to better understand molecular and cellular mechanisms of establishment of T-cell tolerance and its breakdown. These studies will contribute to the development of new tools and strategies for prevention and intervention in autoimmune disorders. The projects we developp and the technics we use are improving my technical and fundamental knowledge in the field of immunology. An E.C. fellowship would give me thepossibility both to finish already promissing research projects and to accomplish my PhD thesis in a E. C. foreign country.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology virology
- natural sciences biological sciences biochemistry biomolecules
- medical and health sciences health sciences infectious diseases viral diseases RNA viruses influenza
- medical and health sciences basic medicine immunology
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
71110 IRAKLION
Greece
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.