Objective
Research objectives and content
The phosphorylation of STAT5 (signal transducers and activators of transcription) activates gene transcription leading to the growth and acquisition of effector functions of -lymphocytes. This phosphorylation has been described as occurring on tyrosine residues but, very recently, D Cantrell's group has shown that a serine phosphorylation was also involved in STAT5 activation. Interestingly, the serine phosphorylation seems to be required for transcription activation by STAT5 following IL2 stimulation. Additional experiments have shown that none of the known pathways that could lead to he serine phosphorylation of STAT5 (MAP-kinase and phosphatidylinositol 3kinase) were involved in that newly described form of STAT5. Therefore, the IL2-activated serine phosphorylation results from a previously uncharacterised serine kinase. The aim of this project is to identify this protein, describe the pathway leading to its activation, and work out its involvement in T-lymphocyte response to IL2.
Training content (objective, benefit and expected impact)
The training objective is to deepen my knowledge of T-lymphocyte activation by studying the intracellular signalling following their stimulation. Its benefits will be 1) to get expertise in analysing signal transduction, which is a key step to every immunological process and 2) to interact with leading researchers in immunology and biochemistry. The knowledge and the scientific contacts gained will be applicable in most areas of lymphocyte biology and beneficial to any European group I may join after this post-doctorate.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences cell biology cell signaling
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine immunology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
WC2A 3PX London
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.