Objective
Research objectives and content
The Y isoform of 14-3-3 has recently been found to be highly sensitive and specific ( 98%) marker in a spinal fluid test for the diagnosis of Creutzfeldt-Jacob disease, CJD in the early clinical stages. Dr Aitken's laboratory has now established that the same isoforms of 14-3-3 are present in cerebrospinal fluid (CSF) samples from humans and cows. Moreover, the isoforms of 14-3-3 present in CSF are principally gamma and Dr Aitken's colleagues have strong evidence for the existence of a phosphorylated form of Y 14-3-3 in brain. The project will therefore focus on the examination of these 14-3-3 isoforms and study of their particular variants (particularly phosphorylation) to test whether changes occur in the brain (and in which tissue). The work will include identification of site(s) of phosphorylation and the identification of the kinase(s) responsible. Training content (obJective, benefit and expected impact)
The finding that 14-3-3 isoform(s) are a highly sensitive and specific marker in the spinal fluid test for the diagnosis in the clinical stages of CJD does not reveal the biological mechanism of onset or transmissibility of the disease. I wish to test changes in phosphorylation of 14-3-3 isoforms in neural tissue and the relationship to the TSE diseases. This may give some indication as to the possible mechanism of onset of the disease and perhaps suggest possible treatment.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
NW7 1AA London
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.