Objective
Research objectives and content
Members of the fibroblast growth factor (FGF) family are implicated as important cell to cell signalling molecule in animal development. The role of FGF signalling in human development has been further highlighted by the demonstration that mutations in FGF receptor-3 are the major cause of human dwarfism, and mutations in other FGF receptors cause several inherited skeletal dysplasias of children. As targeted deletions of FGF receptor-2 are lethal in the mouse at implantation, we plan to use a more delicate approach where only one of the two alternative FGFR-2 isoforms are mutated in the mouse germline. In addition, the approach will generate other lines of mice where the FGF receptor mutations are restricted to specific cell lineages. This will allow us to investigate the significance of FGF signalling in early mammalian development, organogenesis, and homeostatic mechanisms such as wound repair. Training content (objective, benefit and expected impact)
This project will provide training in mouse developmental genetics and mammalian embryogenesis. The results should provide a better understanding of how FGFs affect lineage determination and tissue patterning and may have a direct impact on the understanding of some skeletal dysplasias. Links with industry / industrial relevance (22)
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences cell biology cell signaling
- social sciences other social sciences development studies social developments
- natural sciences biological sciences developmental biology
- natural sciences biological sciences genetics mutation
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
WC2A 3PX London
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.