Objective
Research objectives and content The nicotine is a natural alkaloid with high complex physiological activity. It is widely accepted that nicotine and its agonists could be used for the treatment of Alzheimer'disease, Parkinson's disease and as ansyolitic, antidepressive and schizophrenic therapeutic agents. The low availability of compounds structurally related to nicotine is a serious obstacle for structure activity relationships. Therefore, a novel total synthesis based on the use of polymeric supported reagents should allow the preparation of a large number of similar nicotine derivatives in a automatic fashion. For example, the polymer supported perruthenate (PSP), prepared by the methodology develop by the group of Prof. S.V. Ley, already successful applied in the synthesis of chemical libraries of other natural products. Based on these results we propose here the use of this reagents in two steps of a synthesis of nicotine derivatives based on solid supported reagents. Training content (objective, benefit and expected impact) I consider that the University of Cambridge it is now one of the most important European research centers in Organic Chemistry. During my training stay there, under the supervision of Prof. Steven V. Ley, I expect to improve my knowledge and experience in Synthetic Organic Chemistry: At the moment I have carried out research directed to methodologic aspects and would gain very much by working on a total synthesis project. Links with industry / industrial relevance (22) The understanding of the structure/activity relationship of nicotine and their af antidepressive properties are of great relevance for medicine and the pharmaceutical industry.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine neurology neurodegenerative diseases dementia alzheimer
- natural sciences chemical sciences organic chemistry
- natural sciences chemical sciences polymer sciences
- medical and health sciences basic medicine neurology neurodegenerative diseases parkinson
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
CB2 1EW Cambridge
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.