Development of methods for predictive toxicity testing with reference to neurotoxic volatile chemicals.

Informations projet

RANTIV

N° de convention de subvention: QLK4-CT-1999-01356

Projet clôturé

Date de début 1 Janvier 2000

Date de fin 31 Decembre 2002

Financé au titre de

• Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Coût total € 1 100 065,00

Contribution de l’UE € 1 099 969,00

Coordonné par

KAROLINSKA INSTITUTE
Sweden

Objectif

The present proposal aims at providing innovative tools and more effective methods for mechanism-based risk assessment of neurotoxic compounds. A novel apparatus for the exposure of cell in culture to volatile agents will be developed. In addition selected cell types representing specific molecular neuronal targets for the toxic agents studied (carbon monoxide, hexane and styrene) will be used as in vitro experimental models. The final aim is to find and propose in vitro tests that could reduce the need for animal studies. By investigating a variety of possible end-points and using a multidisciplinary approach, the overall novelty of the project and the likelihood of a major advance in the field are greatly increased.

Champ scientifique

• natural sciences › chemical sciences › inorganic chemistry › inorganic compounds

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Thème(s)

• 1.1.1.-4. - Key action Environment and Health

Appel à propositions

Data not available

Régime de financement

CSC - Cost-sharing contracts

Coordinateur

KAROLINSKA INSTITUTE

• Contribution de l’UE: Aucune donnée
• Adresse: Nobels Vaeg, 13 ; 171 77 STOCKHOLM ; Suède
• Coût total: Aucune donnée

Participants (5)

FONDAZIONE SALVATORE MAUGERI - CLINICA DEL LAVORO E DELLA RIABILITAZIONE

Italie

• Contribution de l’UE: Aucune donnée
• Adresse: Via A. Ferrata 8 ; 27100 PAVIA
• Coût total: Aucune donnée

FUNDACION DE LA COMUNIDAD VALENCIANA CENTRO DE INVESTIGACION PRINCIPE FELIPE

Espagne

• Contribution de l’UE: Aucune donnée
• Adresse: 4,Amadeo de Saboya 4 ; 46010 VALENCIA
• Coût total: Aucune donnée

LEOPOLD-FRANZENS-UNIVERSITAET INNSBRUCK

Autriche

• Contribution de l’UE: Aucune donnée
• Adresse: 52,Christoph-Probst-Platz 1 ; 6020 INNSBRUCK
• Coût total: Aucune donnée

THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN HEREINAFTER TRINITY COLLEGE DUBLIN

Irlande

• Contribution de l’UE: Aucune donnée
• Adresse: Trinity College ; 2 DUBLIN
• Coût total: Aucune donnée

UNIVERSITA DEGLI STUDI DI PARMA

Italie

• Contribution de l’UE: Aucune donnée
• Adresse: VIA UNIVERSITA 12 ; 43100 PARMA
• Coût total: Aucune donnée