Objective
The major objective is to solve the three dimensional structure of two membrane protein complexes using electron crystallography.
1. The complex between the bacterial toxin colicin N and porins. The key point is to visualize structural changes that occur when the initially soluble toxin, mediated by porins, inserts and translocates into membranes. This mechanism is currently poorly understood, but the work is facilitated by availability of two-dimensional crystals of the complex and atomic coordinates of both molecules.
2. Opioid receptors, which mediate analgesic action and the addictive properties of morphine-derived compounds, modulate pain controlling pathways, mood and reward. They belong to the group of trimeric G protein-coupled receptors with seven membrane helices. The structure of these important receptors is not known even at low resolution.
This project will give me an excellent training and knowledge in:
1. Biochemistry and crystallization of membrane proteins
2. High-resolution electron microscopy including specimen preparation, imaging and image processing.
Both projects are potentially important for pharmaceutical industrial interests in toxicology and analgesic /addictive drugs. The Pattus group has also established collaboration with the Astra pharmaceutical company on the functional studies of delta opioid receptor.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences earth and related environmental sciences geology mineralogy crystallography
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences physical sciences optics microscopy electron microscopy
- medical and health sciences basic medicine toxicology
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
67400 ILLKIRCH GRAFFENSTADEN
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.