Objective Glutamate (Glue) is the major mediator of excitatory signals in the central nervous system and both too low and too high levels of Glue are harmful. Glue exerts its signalling function by activating receptors on the cell surfaces. Nervous tissue is an extremely complex network of cellular extensions. Glue receptors are widely distributed within this network; both within and outside synapses. Glue is released at synapses and from other parts of both neurons and supporting cells. Understanding of Glue mediated signalling therefore requires insight into how Glue diffuses between the cellular elements and how it is released into and is removed from the extra cellular fluid. Disturbance of this control likely contributes to several disorders causing suffering and economic losses. The consortium will clarify the mechanisms controlling extra cell. Glue, and will produce a knowledge base for pharmaceutical industry and clinical medicine. Fields of science natural sciencesbiological sciencesneurobiologymedical and health sciencesclinical medicine Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-9. - Neurosciences Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator UNIVERSITY OF OSLO EU contribution No data Address Sognsvannsveien 9 0317 OSLO Norway See on map Total cost No data Participants (5) Sort alphabetically Sort by EU Contribution Expand all Collapse all CELICA D.O.O. Slovenia EU contribution No data Address Stegne 21 1000 LJUBLJANA See on map Total cost No data FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR - ISTITUTO DI RICOVERO E CURA A CARATTERE SCIENTIFICO Italy EU contribution No data Address Via Olgettina 58 20132 MILANO See on map Total cost No data UNIVERSITY COLLEGE LONDON United Kingdom EU contribution No data Address Gower Street LONDON See on map Links Website Opens in new window Total cost No data UNIVERSITY COLLEGE LONDON United Kingdom EU contribution No data Address Queen Square WC1N 3BG LONDON See on map Total cost No data UNIVERSITY OF LAUSANE Switzerland EU contribution No data Address 9,Rue du Bugnon 9 1005 LAUSANNE See on map Total cost No data
