Objective
We will develop novel, specific, therapeutics to treat the model autoimmune disease, myasthenia gravis, which is caused by antibodies to the muscle acetylcholine receptor (Ache). The therapeutics (to be tested extensively in vitro and in vivo experiments) will target different aspects of the immune response and involve
(a) ex vivo immunoadsorption of the anti-Ache antibodies by immobilized polypeptide fragments of the Ache;
(b) protection of the Ache and reduction of B cell activation by modified non-pathogenic engineered monoclonal anti-Ache antibodies;
(c) selection of active subtractions of normal human lag for in vivo intravenous lag (Ivy) therapy; (d) induction of mussel tolerance by the use of recombinant Ache polypeptides;
(e) peptide vaccination against a dominant T cell receptor;
(f) peptide:MHC multimedia complexes to identify T cells ex vivo and tolerate them in vivo; (9) antilogous, Specific-specific, tolerogenic dendrite cells for in vivo use;
(h) combinations of selected therapies; (I) for the more efficient therapies, we will study gene expression levels by micro array technology in order to explore their mechanisms of action, and to identify potential new drug targets.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences biochemistry biomolecules
- medical and health sciences basic medicine immunology autoimmune diseases
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
11521 ATHENS
Greece
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.