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Innovative therapeutics for the prototype autoimmune disease, myasthenia gravis

Project information

Grant agreement ID: QLK3-CT-2001-00225

  • Start date

    1 January 2002

  • End date

    31 December 2005

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 2 466 845

  • EU contribution

    € 1 822 984

Coordinated by:

HELLENIC PASTEUR INSTITUTE

Greece

Objective

We will develop novel, specific, therapeutics to treat the model autoimmune disease, myasthenia gravis, which is caused by antibodies to the muscle acetylcholine receptor (Ache). The therapeutics (to be tested extensively in vitro and in vivo experiments) will target different aspects of the immune response and involve
(a) ex vivo immunoadsorption of the anti-Ache antibodies by immobilized polypeptide fragments of the Ache;
(b) protection of the Ache and reduction of B cell activation by modified non-pathogenic engineered monoclonal anti-Ache antibodies;
(c) selection of active subtractions of normal human lag for in vivo intravenous lag (Ivy) therapy; (d) induction of mussel tolerance by the use of recombinant Ache polypeptides;
(e) peptide vaccination against a dominant T cell receptor;
(f) peptide:MHC multimedia complexes to identify T cells ex vivo and tolerate them in vivo; (9) antilogous, Specific-specific, tolerogenic dendrite cells for in vivo use;
(h) combinations of selected therapies; (I) for the more efficient therapies, we will study gene expression levels by micro array technology in order to explore their mechanisms of action, and to identify potential new drug targets.

Coordinator

HELLENIC PASTEUR INSTITUTE

Address

127,Vassilissis Sofias Av. 127
11521 Athens

Greece

Participants (7)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

France

DIAMED EUROGEN N.V.

Belgium

KAROLINSKA INSTITUTE

Sweden

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

United Kingdom

UNIVERSITE DE PARIS-SUD XI

France

UNIVERSITY OF MAASTRICHT

Netherlands

WEIZMANN INSTITUTE OF SCIENCE

Israel

Project information

Grant agreement ID: QLK3-CT-2001-00225

  • Start date

    1 January 2002

  • End date

    31 December 2005

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 2 466 845

  • EU contribution

    € 1 822 984

Coordinated by:

HELLENIC PASTEUR INSTITUTE

Greece