Objective An optimal immunotherapeutic regimen will be established and its efficacy evaluated in HIV-infected individuals. The proposal comprises the improvement of an adjuvant protein HIV vaccine for therapeutic use that has proved efficacious in a stringent rhesus monkey SHIV challenge rode. The irnprovement will be achieved through combination of the adjuvant protein vaccine with particle-mediated immune delivery of DNA in prime-boost immunization regimen. This regimen will be investigated in mice and rhesus monkeys for superior immunogenicity and efficacy. One or several prime-boost immunization regimen will be evaluated in initial phase I clinical trials in exonerative volunteers. If the prime-boost combinations are immunogenic, the best combination will be tested for its efficacy in a therapeutic trial in HIV-Positive patients. Fields of science medical and health sciencesbasic medicineimmunologyimmunisationnatural sciencesbiological sciencesgeneticsDNAnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health scienceshealth sciencesinfectious diseasesRNA virusesHIVmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-2. - Key action Control of Infectious Diseases Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator GLAXOSMITHKLINE BIOLOGICALS SA EU contribution No data Address Rue de l'Institut 89 --- RIXENSART Belgium See on map Total cost No data Participants (2) Sort alphabetically Sort by EU Contribution Expand all Collapse all FOUNDATION BIOMEDICAL PRIMATE RESEARCH CENTRE Netherlands EU contribution No data Address 157,Lange Kleiweg 139 2288 GJ RIJSWIJK ZH See on map Total cost No data SWEDISH INSTITUTE FOR INFECTIOUS DISEASE CONTROL Sweden EU contribution No data Address Nobels vaeg 18 SOLNA See on map Links Website Opens in new window Total cost No data
