Objective
The proposed projects will exploit state of the art approaches to the identification of novel proteins important in Asthma and Rheumatoid arthritis. One fellow will focus on increasing our understanding of genes which are differentially expressed in disease tissue but which have little or no functional annotation. The role of these genes will be studied using detailed expression profiling in biopsies and primary cells from patients, as well as cell lines and samples from animal models of disease. Function will be studied by over expression and knockout studies, as well as antisense, antibody approaches. The second research fellow will pursue an approach combining unique in house structural knowledge with a prateomics strategy to increase our of the molecular interactions involved in regulation of the glucocorticoid receptor. Glucocorticoids are widely recognized as the most effective anti-inflammatory agents, however their cellular and molecular modes of action are still far from being fully elucidated. The proteomics strategy, combined with a cell based approach using functional readouts will lead to novel and therapeutically relevant insights into the treatment of inflammatory disease.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine pneumology asthma
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- medical and health sciences clinical medicine rheumatology
- medical and health sciences health sciences inflammatory diseases
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
SG1 2NY STEVENAGE
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.