Objective
In the last years, considerable effort has been directed to unravel the mechanisms involved in these recognition processes by the design of peptide derived receptors for the selective binding of glycoconjugates. This project will be addressed towards this aim and it will be focused on the development of cyclic peptide receptors for the selective binding of carbohydrates. By using solid-phase combinatorial organic chemistry methodologies, libraries of receptors will be synthesized and screened towards different sugars (e. g. mono- and disaccharides), depending on the cavity shape and size. It is intended to create an efficient tool for the elucidation of the geometric requirements needed for efficient carbohydrate complexatian. Furthermore, due to the enzymatic stability of cyclic peptides as compared to their linear counterparts, these receptors may be interesting targets for drug discovery. The design of these receptors will be based on the stabilizing interaction between the a-face of monosaccharides and aromatic surfaces embedded into a peptide backbone, which may trigger additional interactions between the carbohydrate and the peptide (mostly hydrogen bonds). The modification of the receptor elements in a combinatorial fashion may lead to identification of tight complexes ( e. g. fluorescence assays, BIAcore) which structure will be analyzed (e. g. MALDI- TOF, NMR, Edman degradation, molecular modeling) to obtain the complete interaction pattern between sugar hydroxyl groups and peptide amido groups. Structure/binding efficiency relationship will also be determined towards the development of saccharide bio-sensors, drug or selective carbohydrate transport systems. This project offers the candidate the possibility to improve his knowledge in solid-phase organic chemistry methodologies, not only in the peptide field not so in others, including carbohydrates. Furthermore, it will give the candidate an essential formation in combinatorial chemistry and library screening techniques (e. g. on-bead fluorescence assays to detect lead compounds, NMR for structure characterization, or surface plasmon resonance to disclose the thermodynamic parameters of complexation). The acquired knowledge will be very useful for the candidate in the development of his further projects linked to the understanding of the interaction between proteins and carbohydrate, which play an elemental role in biological processes and may lead to biomedical applications.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- natural sciences physical sciences condensed matter physics quasiparticles
- natural sciences chemical sciences organic chemistry
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences biochemistry biomolecules carbohydrates
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
2500 VALBY
Denmark
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.