Objective
The renewal of gut cells requires the correct control of stem cell proliferation and differentiation. Defects in these key events are responsible for pathologies, such as cancers and developmental abnormalities. The evolutionarily conserved Notch signaling pathway is implicated in the control of cell proliferation and differentiation. The role of this pathway in gut will be primarily studied in zebra fish which is suitable for in vivo experiments. We will first describe the normal pattern of cell types and population dynamics in the zebra fish hindgut. This part will require the use of a reporter gene such as GFP. On the basis of these observations, the analysis will then be performed in Notch pathway zebra fish mutants already available (mind bomb, after eight, deadly seven) or in zebra fishes with artificial gene misexpression. Finally, gut cell differentiation studies will also be performed in mice carrying mutations of the Notch signaling pathway. Because most of the mutations are embryonic lethal, this study will require to graft embryonic mouse gut rudiments sub-multaneous into nude mice and study the development and differentiation of the segments of gut. Results should show if the same conclusions are true for zebra fish and mouse, and should help to gain insight into mechanisms of vertebrate gut development.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences medical biotechnology cells technologies stem cells
- natural sciences biological sciences genetics mutation
- medical and health sciences clinical medicine oncology
- medical and health sciences basic medicine pathology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
WC2A 3PX LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.