Objetivo Cancer can be considered a disease of communication at molecular level. The area of cell signalling investigates the transmission of information from receptors to gene activation by means of biochemical reaction pathways that form complex signalling networks and impinge on development and health of organisms. COSBICS is to establish and apply a novel computational framework in which to investigate dynamic interactions of molecules within cells. Instead of simply mapping proteins in a pathway, COSBICS is concerned with "dynamic pathway modelling". Dynamic pathway modelling establishes mathematical models to quantitatively predict the spatial-temporal response of signalling pathways and subsequent target gene expression. To understand how biochemical networks make decisions, the dynamic interactions of proteins are important rather than just creating static maps of involved components. Our previous work has shown that mathematical modelling does provide practical, useful tools to design experiments and allows hypotheses testing to generate new biological knowledge. For this, a multidisciplinary approach combining an iterative modelling process with advances in quantitative data generation is essential. This requires close interaction between experimental groups, data analysts and modellers. The aim is to develop methodologies that are generic in the sense that they are applicable to signalling networks in general, and as independent of the organism as possible. Towards this end, this project is to consider two important systems: the Ras/Raf/MEK/ERK pathway and the JAK-STAT pathway. COSBICS is to investigate with these pathways the heart of the intracellular communication network that governs cell growth, differentiation and survival. Combining mathematical modelling with biology, COSBICS will improve our understanding of how these two central communication networks are subverted in tumour cells and thus promote the generation of new knowledge in fucntional genomics. Ámbito científico natural sciencesbiological sciencesgeneticsnatural sciencesbiological sciencescell biologycell signalingnatural sciencesmathematicspure mathematicsmathematical analysisnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural sciencesmathematicsapplied mathematicsmathematical model Palabras clave Dynamic modelling of pathways signal transduction Programa(s) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Tema(s) LSH-2003-1.1.0-1 - Topics for Specific Targeted Research Project in the area of Fundamental knowledge and basic tools for functional genomics in all organisms Convocatoria de propuestas FP6-2003-LIFESCIHEALTH-I Consulte otros proyectos de esta convocatoria Régimen de financiación NoE - Network of Excellence Coordinador UNIVERSITÄT ROSTOCK Aportación de la UE Sin datos Dirección Universitätsplatz 1 ROSTOCK Alemania Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos Participantes (5) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo DEUTSCHES KREBSFORSCHUNGSZENTRUM Alemania Aportación de la UE Sin datos Dirección Im Neuenheimer Feld 280 HEIDELBERG Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos BEATSON INSTITUTE FOR CANCER RESEARCH Reino Unido Aportación de la UE Sin datos Dirección Garscube Estate, Swichback Road Bearsden GLASGOW Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS España Aportación de la UE Sin datos Dirección Serrano, 117 MADRID Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos INSTITUTE OF MECHANICS TO THE BULGARIAN ACADEMY OF SCIENCES Bulgaria Aportación de la UE Sin datos Dirección 1, 15 Noemvri Str. SOFIA Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos ALBERT-LUDWIGS-UNIVERSITÄT FREIBURG Alemania Aportación de la UE Sin datos Dirección Fahnenbergplatz FREIBURG Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos
