Objective
This project intends to explore and validate new targets and pathways for innovative treatment of solid tumors directed towards tumor vascular matrix interactions, define validated targets towards tumour neovessel formation and create effective and tumour-selective strategies that complement or subsitute established therapies. The apparent lack of success in translating angiogenesis research into the clinic is in our view based on the fact that the research field is fragmented, and no standardized tools and models have been identified that reliably reflect the complexity of tumour angiogenesis mechanisms in humans. This integrated project will identify and validate new therapeutic targets directed towards tumor vascular-matrix interactions, develop new therapeutic strategies and implement such strategies in pre- and clinical trials. The project will represent a virtual research institute ine Europe and consists of 14 higly competent research centers within the field of angiogenesis research. To define and validate new targets related to the tumour vascular transcriptome and proteome, the consortium will etablish high throughput functional screening technologies for the identification of novel secreted factors that regulate endothelial cell growth and survival. This includes the use of robotics platforms that will be used to identify cDNAs with specific cellular functions. In this application, basic science, translational research and clinical activities are strongly intergrated, in order to validate defined targets and new therapeutic principles for clinical implementation.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- engineering and technology electrical engineering, electronic engineering, information engineering electronic engineering robotics
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-LIFESCIHEALTH
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
BERGEN
Norway
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.