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European systems biology initiative for combating complex diseases

Objective

Primary targets of FP6 are activities for the combat of multigenic complex diseases such as cancer, diabetes and heart diseases. These diseases, like many others, are caused by disturbances in the complex networks of biological processes in the organisms. Prevention, diagnosis and therapy of these diseases require a detailed understanding of these processes in health and disease, based on the application of techniques from the area of functional genomics on the individual patient, combined with the development of modelling systems, that are able to model the disease process, based on available information as well as the information gained on the individual (genetic factors, chromosomal changes, expression patterns on the RNA and protein levels etc.). In this coordination action (CA) we propose to develop a European infrastructure for such a systems biology approach to combat complex diseases. While we plan to focus on cancer in our initial work, we expect this approach and infrastructure component to become a key instrument in improving diagnosis and therapy of many other complex diseases. This proposal will unite the effort of groups at the forefront of systems biology and modelling, of functional genomics and some of the foremost centres of cancer research. Major goals will be to integrate data and analysis resources available at the participating centres, as well as other centres world wide, to develop and use new mechanisms to identify the pathways likely to be most relevant to the problem domain (cancer), to incorporate these into the models, and to carry out benchmarking studies on the pilot scale to identify strength and weaknesses of current approaches. A major effort will be also invested into a strong outreach component, designed to create local networks contributing to the work of each center, and to educate researchers throughout Europe to the new possibilities and concepts.

Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

MAX PLANCK SOCIETY REPRESENTED BY THE MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS

Address

Ihnestr. 73
Berlin

Germany

Administrative Contact

Ralf HERWIG (Dr)

Participants (7)

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DEUTSCHES KREBSFORSCHUNGSZENTRUM

Germany

ASSOCIATION POUR LA RECHERCHE ET LE DÉVELOPPEMENT DES MÉTHODES ET PROCESSUS INDUSTRIELS

France

TEL-AVIV UNIVERSITY

Israel

PATERSON INSTITUTE FOR CANCER RESEARCH CHRISTIE HOSPITAL NHS TRUST

United Kingdom

INSTITUT CURIE

France

MEDICAL UNIVERSITY GRAZ

Austria

THE UNIVERSITY OF MANCHESTER

United Kingdom

Project information

Grant agreement ID: 518192

  • Start date

    1 November 2005

  • End date

    31 October 2007

Funded under:

FP6-LIFESCIHEALTH

  • Overall budget:

    € 350 000

  • EU contribution

    € 350 000

Coordinated by:

MAX PLANCK SOCIETY REPRESENTED BY THE MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS

Germany