Skip to main content

Breath-gas analysis for molecular-oriented detection of minimal diseases

Objective

Cancer is one of the leading causes of death in the western world. Diagnosis of cancer often happens late in the course of the disease since available diagnostic methods are not sufficiently sensitive and specific. An early diagnosis of cancer could save thousands of lives a year. There is strong evidence that particulate cancers can be detected by molecular analysis of exhaled air. Breath analysis represents a new non-invasive diagnostic which can provide information beyond conventional analysis of blood and urine. Recent results suggest that detection of cancer is possible by means of breath analysis in very early stages of the disease. This project is focused onto the diagnosis of minimal disease and early stages of lung and oesophageal cancer. The analytical techniques used will be GC-MS, PTR-MS, SIFT-MS and laser spectrometry. In order to establish a reliable clinical method for the diagnosis of minimal residual cancer diseases clinical expertise, basic research and technical development is necessary. The European consortium set up for this proposal represents exquisite knowledge in the field of basic and clinical research and technical development. Based on its competence, the consortium has the expertise to investigate and screen for hundreds of molecules in the exhaled breath and the statistical tools to identify specific cancer markers. The objectives of the project are - the development of sensitive and specific markers for the detection of early cancer stages based on human breath - reliable analytical methods to determine these markers in the clinical environment - easy-to-use and non-expensive equipment establishing breath analysis as a novel cancer screening tool. To get a better understanding of the interplay between blood and breath concentrations of volatile components, the blood-gas kinetics will be modeled. Two SMEs will devesubsequent use in clinical applications.

Call for proposal

FP6-2004-LIFESCIHEALTH-5
See other projects for this call

Funding Scheme

STREP - Specific Targeted Research Project

Coordinator

MEDIZINISCHE UNIVERSITÄT INNSBRUCK
Address
Christoph-probst-platz 1
Innsbruck
Austria

Participants (12)

UNIVERSITÄT ROSTOCK, MEDIZINISCHE FAKULTÄT
Germany
Address
Schillingallee 35
Rostock
LEOPOLD-FRANZENS-UNIVERSITÄT INNSBRUCK
Austria
Address
Innrain 52
Innsbruck
VORARLBERG UNIVERSITY OF APPLIED SCIENCES
Austria
Address
Achstrasse 1
--- Dornbirn
IMPERIAL COLLEGE LONDON
United Kingdom
Address
Icl South Kensington Campus
London
NICOLAUS COPERNICUS UNIVERSITY
Poland
Address
Gagarina 11
Torun
SLOVAK ACADEMY OF SCIENCES
Slovakia
Address
Dubravska Cesta 9
Bratislava
IT DR. GAMBERT GMBH
Germany
Address
Hinter Demchor 21
Wismar
IONIMED ANALYTIK GMBH
Austria
Address
Technikerstrasse 54
Innsbruck
TRANS SPECTRA LIMITED
United Kingdom
Address
9 The Elms, Porthill
Newcastle Under Lyme, Staffordshire
ISAS - INSTITUTE FOR ANALYTICAL SCIENCES
Germany
Address
Bunsen-kirchhoff-str. 11
101352 Dortmund
THE HENRYK NIEWODNICZANSKI INSTITUTE OF NUCLEAR PHYSICS POLISH ACADEMY OF SCIENCES
Poland
Address
Radzikowskiego 152
--- Krakow
UNIVERSITÄTSKLINIKUM DÜSSELDORF
Germany
Address
Universitätsstr. 1
Düsseldorf