Objectif The overall objective of the proposed work is to contribute to an increased knowledge about the effect ofpraziquantel on schistosomiasis related morbidity, the mechanisms behind this effect both regarding theregulation of host immune responses as well as t he effect on the parasite with the overall aim of improving thestrategies for morbidity control and it thus address the strategic objective relating to "New knowledge on biology,epidemiology and technologies relevant for sustainable surveillance systems of diseases on a regional scale; oninnovation in and improvement of existing interventions and help to implement appropriate strategies andpolicies for prevention, control and treatment" of vector-borne diseases such as schistosomiasis".In order to reach the overall objective of improving strategies for control we are aiming at the following researchrelated outcomes: 1) Increased knowledge about the dynamics of morbidity and how it may be affected andmodulated by treatment and 2) increased knowledge about the effect of PZQ on the host immune responses and3) non-invasive and reliable ways of detecting morbidity.Field studies with pre- and post treatment assessment of infection and morbidity status will take place in Uganda,Kenya and Mali and address both Schist osoma mansoni and S. haematobium infections. Champ scientifique medical and health scienceshealth sciencespublic healthepidemiologynatural sciencesbiological sciencesbiochemistrybiomoleculesmedical and health sciencesbasic medicineimmunologymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Programme(s) FP6-INCO - Specific measures in support of international cooperation: Specific activities covering wider field of research under the Focusing and Integrating Community Research programme 2002-2006. Thème(s) INCO-2003-A1.3 b - Knowledge and technologies to improve control of neglected communicable diseases Appel à propositions FP6-2003-INCO-DEV-2 Voir d’autres projets de cet appel Régime de financement STIP - Specific Targeted Innovation Project Coordinateur UNIVERSITY OF COPENHAGEN Contribution de l’UE Aucune donnée Adresse Nørregade 10 COPENHAGEN K Danemark Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée Participants (6) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire Chancellor, Masters and Scholars of the University of Cambridge Royaume-Uni Contribution de l’UE Aucune donnée Adresse THE OLD SCHOOLS TRINITY LANE CAMBRIDGE Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée Division of Vector Borne Diseases, Ministry of Health Kenya Contribution de l’UE Aucune donnée Adresse NAIROBI Voir sur la carte Coût total Aucune donnée Institut National de Recherche en Santé Publique Mali Contribution de l’UE Aucune donnée Adresse Rue Amilcar Cabral 235 BAMAKO Voir sur la carte Coût total Aucune donnée Kenya Medical Research Institute Kenya Contribution de l’UE Aucune donnée Adresse MBAGATHI ROAD NAIROBI Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée Leiden University Medical Center Pays-Bas Contribution de l’UE Aucune donnée Adresse Albinusdreef 2 LEIDEN Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée Vector Control Division, Ministry of Health of Government of Uganda Ouganda Contribution de l’UE Aucune donnée Adresse 15 Bombo Road KAMPALA Voir sur la carte Coût total Aucune donnée
