Objetivo Schistosomiasis is an important parasitic disease in the developing world and is largely chronic in nature. Helminth infections, such as Schistosoma sp., often cause down-regulation of the adaptive immune response possibly through long-term, or repeated stimulation of the innate immune system following binding of parasite molecules to a limited number of innate receptors (e.g. Toll-like receptors). This aspect of the immune system represents a novel route to exploit in future control programs.Therefore, our proposal has four objectives.1. We will investigate differences in the innate immune response, specifically of innate receptors in groups of individuals with different histories of infection and extent of pathology, which will be further dissected in models of infection.2 Glycan structures on molecules released by schistosomes are important candidate ligands of host innate receptors and so will be characterised, isolated and synthesised.3 Isolated molecules will be tested using human in vitro assays and in vivo model systems, to identify those molecules with the greatest capacity to enhance or regulate immune responsiveness. These molecules bear promise as potential adjuvants in drug and vaccine control programmes, or as therapeutics to control pathology.4 Finally, Geographical Information Systems will be applied to link features of the innate immune response to the history of exposure, and expression of pathology.This framework will facilitate the implementation of drug and vaccine control programmes to those most at risk. The proposal is based upon a multidisciplinary and integrated consortium bringing together field based researchers (epidemiologists, health care workers), statisticians, and basic scientists (immunologists, biochemists) from 3 African and 3 European countries. Together, the partners will deliver an innovative project that will identify novel strategies that will aid the control of schistosomiasis. Ámbito científico humanitieshistory and archaeologyhistorymedical and health sciencesbasic medicineimmunologymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccinesnatural sciencesbiological sciencesbiochemistrybiomoleculescarbohydratesmedical and health sciencesbasic medicinepathology Programa(s) FP6-INCO - Specific measures in support of international cooperation: Specific activities covering wider field of research under the Focusing and Integrating Community Research programme 2002-2006. Tema(s) INCO-2004-A1.3 - Knowledge and technologies to improve control of neglected communicable diseases Convocatoria de propuestas FP6-2004-INCO-DEV-3 Consulte otros proyectos de esta convocatoria Régimen de financiación STREP - Specific Targeted Research Project Coordinador UNIVERSITY OF YORK Aportación de la UE Sin datos Dirección Heslington YORK Reino Unido Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos Participantes (5) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo HOPITAL ALBERT SCHWEITZER Gabón Aportación de la UE Sin datos Dirección LAMBARENE Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos Leiden University Medical Center Países Bajos Aportación de la UE Sin datos Dirección Albinusdreef 2 LEIDEN Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos NOGUCHI MEMORIAL INSTITUTE FOR MEDICAL RESEARCH Ghana Aportación de la UE Sin datos Dirección Legon ACCRA Ver en el mapa Coste total Sin datos PRINCE LEOPOLD INSTITUTE OF TROPICAL MEDICINE Bélgica Aportación de la UE Sin datos Dirección Nationalestraat 155 ANTWERP Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos UNIVERSITE CHEIKH ANTA DIOP Senegal Aportación de la UE Sin datos Dirección Avenue Martin Luther King DAKAR FANN Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos