Objective
As a newly recruited scientist my project aims at validate the strategy consisting in the neutralization of thrombospondin-1 (TSP-1) as a pharmacological approach for the treatment of thrombosis, and for the development of an anti-cancer therapy based on t he properties of TSP-1 in metastasis and angiogenesis. In close collaboration with my postdoctoral host, we will study the contribution of TSP-1 in platelet recruitment onto vessel wall, in vivo, with the use of TSP-1 null mice in models of inflammation an d thrombosis monitored in situ by intravital videomicroscopy; bone marrow transplantation between wild type and TSP-1-/- mice; in vitro, with the identification of cell-receptors of TSP-1 important for platelet adhesion and aggregation. Platelets are favouring metastasis by participating in tumour cells adhesion and extravasations through the vessel wall. Since TSP-1 is a major platelet component, we will investigate its role in platelets/tumour cells/endothelium interactions.
The work will be conduced in WT and TSP-1-/- mice; by tracking platelets/tumour cells conjugates interacting with the endothelium using intra vital microscopy. Because cancer is often associated with inflammation and thrombosis, which, in turn, favour metastasis, we will use in vivo and in vitro models to study the role of TSP-1 in these processes TSP-1 is an anti-angionegic protein. However the N-ter TSP-1 fragment is pro-angiogenic. Using both in vitro and in vivo models, we will evaluate whether the production of the fragment correlates with the extent of angiogenesis, and whether its neutralization is an efficient anti-angiogenic strategy for anti-cancer therapy. I initiated the creation in the reintegration host, of a structure operating the in vivo models that I developed during my pos t-doc. The structure will be used to complete my project and will be utilized as a shared facility to encourage collaborative works within the institute and to attract collaborators from outside.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine angiology vascular diseases
- medical and health sciences clinical medicine oncology skin cancer melanoma
- medical and health sciences clinical medicine hematology
- medical and health sciences clinical medicine transplantation
- medical and health sciences basic medicine pharmacology and pharmacy
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-11
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.