Objectif The mammalian phosphoinositide (PI) 3-kinase-related kinase mTOR (mammalian target of rapamycin) occupies a central role in a signalling pathway involved in the control of cell growth and proliferation. It integrates signals arising from nutritional cues as well as hormones/growth factors to regulate growth by altering translation and transcription programs.Not surprisingly, alterations in this pathway has been directly linked to a number of disease states including cancer. The host laboratory has recently discovered a novel evolutionary conserved protein, termed URI, that operates downstream of TOR in both yeast and mammalian cells to contribute, directly or indirectly, to rapamycin-sensitive gene expression.In this proposal, we aim at- elucidating the function(s) of URI in cell growth and proliferation in mammalian cells,- determining the significance of rapamycin-sensitive phosphorylation of URI in modulating its function in growth control and gene expression and- identifying novel interaction partners of URI. The proposed studies will provide new leads towards a clearer understanding of URI function(s) in cell growth and proliferation and the mechanism underlying the control of cell growth and gene expression by mTOR. Champ scientifique natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesclinical medicineoncologynatural sciencesmathematicspure mathematicsmathematical analysisfunctional analysis Mots‑clés TOR cancer cell growth nutrient signalling transcription Programme(s) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Thème(s) MOBILITY-2.1 - Marie Curie Intra-European Fellowships (EIF) Appel à propositions FP6-2002-MOBILITY-5 Voir d’autres projets de cet appel Régime de financement EIF - Marie Curie actions-Intra-European Fellowships Coordinateur EIDGENOSSISCHE TECHNISCHE HOCHSCHULE ZURICH Contribution de l’UE Aucune donnée Adresse Rämistrasse 101 ZURICH Suisse Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée
