Objective
Despite increasing knowledge about stroke, treatment options remain unsatisfactory. Because the transfer of neuroprotective agents from the animal model to the patient has turned out to be problematic, there is tremendous interest in new ways of neuroprotection that might be feasible in humans also, such as the induction of endogenous cerebral protection. These mechanisms have been shown to be inducible by a sublethal toxic stimulus in vitro and in animal models ("preconditioning", "Ischemic tolerance"). In a recent study on stroke patients with antecedent transient ischemic attacks, the applicant found evidence for the existence of ischemic tolerance in the human brain.
The proposed project will address the following questions:
1) What factors elicited by preconditioning cause ischemic protection?
2) Is there a specific tissue ¿signature¿ of preconditioned tissue?
3) What distinguishes preconditioned tissue in a following ischemia from first ever ischemic brains?
Magnetic Resonance Imaging (MRI) will be applied to a rat model of hypoxic preconditioning and focal ischemia, to assess parameters of cerebral perfusion and tissue integrity and their spatial and temporal relation to the development of tolerance. To identify a vascular component of preconditioning, MRI at 7 Tesla will include highly sophisticated arterial spin labelling techniques for perfusion-weighted imaging, developed at the host institution. Co-registered histological data will provide information on the extent and character of ischemia-induced neuro genesis.
This comprehensive approach will allow addressing our principal hypothesis: induction of ischemic tolerance is facilitated by a concerted process of protective mechanisms on cellular and vascular level, rather than by independent single events. The transfer of expertise to the Berlin Neuroimaging Centre will provide new MRI technology and exciting options for co-operation, thereby contributing to European science competitiveness.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine neurology stroke
- engineering and technology medical engineering diagnostic imaging magnetic resonance imaging
- natural sciences biological sciences histology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-6
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
OIF - Marie Curie actions-Outgoing International Fellowships
Coordinator
ZURICH
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.