Objective
Growth factor receptor signalling controls an enormous variety of biological processes, during all stages of animal development and in all tissues and organs. Its importance for the understanding and treatment of human disease can not be overstated. Internalization and intracellular transport has emerged as an important regulator of signal transduction by growth factor receptors. Two parallel strategies will be used to tackle this paradigm shift and exploit the opportunities laying behind it: 1) a join t research program involving 12 teams at the international forefront of the field with the aim to understand how receptor internalization and intracellular traffic regulate signalling and biological responses in both health and disease. We will address th e functional genomics of receptor endocytosis and intracellular transport, and elucidate the molecular mechanisms by which these processes affect growth factor signalling. We will identify new genes and potential drug targets in the endocytic and intracellular transport pathways. We will build mathematical models that recapitulate receptor endocytosis and signalling in space and time, and devise chemical and genetic strategies to modify cellular responses to growth factor signalling by manipulating intracellular trafficking of receptor complexes. 2) a multidisciplinary training scheme for a cohort of 6 PhD students and 6 postdoctoral fellows from throughout Europe. They will collaborate with at least 2 centres, and participate in 12 specialist Workshops in a addition to network meetings. They will gain hands-on experience in cutting-edge techniques from across cell biology, genetics, chemistry and mathematics, and also be trained in other approaches and professional skills. This will create a community of young scientists for whom thematic and trans-national mobility will be first nature, giving them the opportunity to become future leaders in the field, either as academics or in EU industry.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences cell biology
- natural sciences biological sciences genetics mutation
- natural sciences mathematics applied mathematics mathematical model
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-1
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
STOCKHOLM
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.