Objective The mammalian genome is packaged into a dynamic structure known as chromatin. There are a range of mechanisms - often referred to as 'epigenetic' controls -that alter its structure and function. These include post-translational modifications, histone variants, and non-coding RNAs. Considerable efforts have been directed at deciphering the epigenetic mechanisms that govern vital biological events such as centromere maintenance, cell-fate determination during development and targeted-recombination. Chromatin pathways are receiving increasing attention as drug targets, since epigenetic components lead to major human diseases such as cancer and heart disease. The complexity of the underlying molecular events, combined with the rapid pace of technological progress and specialization, calls for an integrated effort taking ull advantage of synergistic in vitro, in vivo, clinical and therapeutic approaches. We focus our work on specialized histones, non-coding RNAs and miRNAs. In addition, we analyze how alternative splicing and chromatin-binding metabolites directly influence chromatin structure. This is complemented by novel RNA tools, statistical methods, conceptual breakthroughs, therapeutic targets and patentable lead compounds. We build an innovative and strong training initiative that will expose ESRs to the best-of-practice approaches and scientific interdisciplinarity across academia and industry. Further, we will improve existing standards of training and career development for ERs, which to date has not received as much attention, yet is vital to promote life science and the development of talented and independent researchers. Our multidisciplinary and intersectorial RTN prepares the next generation of European scientists to the highest standards and will reveal novel mechanisms of chromatin plasticity. Fields of science natural sciencesbiological sciencesdevelopmental biologynatural sciencesbiological sciencesgeneticsRNAmedical and health sciencesclinical medicineoncologyleukemianatural sciencesbiological sciencesgeneticsgenomesnatural sciencesbiological sciencesmolecular biologystructural biology Keywords Biochemistry Biophysics Cell biology Computational biology Drug design Epigenetics High-resolution confocal microscopy Imaging Immunology Programme(s) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Topic(s) MOBILITY-1.1 - Marie Curie Research Training Networks (RTN) Call for proposal FP6-2005-MOBILITY-1 See other projects for this call Funding Scheme RTN - Marie Curie actions-Research Training Networks Coordinator EUROPAISCHES LABORATORIUM FUER MOLEKULARBIOLOGIE - EMBL EU contribution No data Address Meyerhofstr.1 HEIDELBERG Germany See on map Links Website Opens in new window Total cost No data Participants (11) Sort alphabetically Sort by EU Contribution Expand all Collapse all THE HEBREW UNIVERSITY OF JERUSALEM. Israel EU contribution No data Address The Hebrew University, Mt. Scopus JERUSALEM See on map Links Website Opens in new window Total cost No data INSTITUTO DE MEDICINA MOLECULAR Portugal EU contribution No data Address Av. Prof. Egas Moniz LISBOA See on map Links Website Opens in new window Total cost No data MEDIZINISCHE UNIVERSITAET WIEN Austria EU contribution No data Address Spitalgasse 23 WIEN See on map Links Website Opens in new window Total cost No data SABANCI UNIVERSITESI Türkiye EU contribution No data Address Orhanli Tuzla TUZLA See on map Links Website Opens in new window Total cost No data CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) France EU contribution No data Address Rue Michel-Ange 3 PARIS See on map Links Website Opens in new window Total cost No data KOBENHAVNS UNIVERSITET Denmark EU contribution No data Address Noerregade 10 KOBENHAVN See on map Links Website Opens in new window Total cost No data SANTARIS PHARMA A/S Denmark EU contribution No data Address Boge Alle 3 KORSHOLM See on map Links Website Opens in new window Total cost No data DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG Germany EU contribution No data Address Im Neuenheimer Feld 280 HEIDELBERG See on map Links Website Opens in new window Total cost No data INSTITUTES DE RECHERCHES CLINIQUES DE MONTREAL Canada EU contribution No data Address Avenue des Pins Ouest 110 MONTREAL See on map Links Website Opens in new window Total cost No data MEDICAL RESEARCH COUNCIL United Kingdom EU contribution No data Address 20 Park Crescent LONDON See on map Links Website Opens in new window Total cost No data BAYER SCHERING PHARMA AKTIENGESELLSCHAFT Germany EU contribution No data Address Müllerstraße BERLIN See on map Total cost No data
