Objective
Atopic Dermatitis (AD, also known as eczema) is a chronic inflammatory skin disease affecting 10-20% of children in western societies. AD is a complex disease arising from the interaction between genetic and environmental factors.
Various genome-wide linkage scans have been undertaken to search for AD susceptibility genes with potential sites identified at various chromosomal locations. However, very little is known about AD causatives genes.
The aim of this project will be the identification of the genetic determinants of AD through genome-wide association. The Affymetrix GeneChip® Mapping 500K Set will be used for the analysis of more than 500.000 Single Nucleotide Polymorphisms (SNPs) on each individual.
The sample will consist of 250 nuclear families (10 00 individuals) selected on the basis of siblings with early onset AD and high/moderate disease severity. Statistical analyses of the acquired data will allow the determination of the SNPs associated to AD and will permit the characterisation of novel AD susceptibility genes.
Additionally, the Affymetrix Human Genome U133 Set GeneChip array will be used to perform a gene expression analysis in T lymphocytes in a subset of 50 AD families. Gene expression profiling will enable the study of correlations between mRNA levels and disease status and severity.
Since the SNPs genotypes will be available, linkage and association analysis will be performed in order to identify the genes regulating the mRNA expression levels and their potential relation with AD.
The present project will enable the applicant to acquire expertise in state of the art tools for complex disease mapping, including high throughput genotyping and statistical genetics. Moreover, this will be achieved in a multidisciplinary setting where biotechnology and functional genomics meet clinical research.
The fellowship will help the applicant to pursue his goal to become an independent and leading scientist in complex disease gene mapping.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine dermatology
- natural sciences biological sciences genetics mutation
- natural sciences biological sciences genetics nucleotides
- natural sciences biological sciences genetics chromosomes
- natural sciences biological sciences genetics genomes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
BERLIN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.