Objective
Dopamine signaling is one of the major pathways of modulatory neurotransmission in the brain. Dysfunctions of the dopaminergic system are involved in several neurological and psychiatric disorders. Investigation of the function of the different dopamine receptors will shed further light on the role of dopaminergic neurotransmission in the brain and increase our understanding of the pathogenic mechanisms involved in dopamine-related disorders. Previous work by the host laboratory has indicated that mice with targeted inactivation of the dopamine D2 receptor (D2R) exhibit higher degree of epileptic seizures and increased neuronal cell death when treated with glutamatergic or cholinergic agonists. These results and recent work by other laboratories that has suggested the implication of D2R in neuronal degeneration in Parkinson and apos;s disease have raised the question of what are the molecular mechanisms that underlie control of neuronal survival by D2R. The proposed project aims to address this question by the use of existing and novel genetically modified mouse models and of a cell culture system. The mouse lines that will be used are D2R-deficient mice and mice lacking either one of the two alternatively spliced D2R isoforms. Neuronal cell death induced by epileptogenic agents or by a parkinsonism-causing neurotoxin will be examined in mutant and control mice by morphological and stereological methods and the degree of epileptic and parkinsonian phenotypes will be assessed by behavioural testing. Alterations in potentially underlying molecular pathways will be studied by biochemical and gene expression analyses. To investigate what changes in cellular physiology may be associated with neuronal loss mediated by D2R dysfunction, a system of cultured primary striatal neurons will be used, as well as electrophysiological measurements, performed in collaboration, using mouse brain slices.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine psychiatry
- natural sciences biological sciences genetics RNA transcriptomes
- medical and health sciences basic medicine physiology
- medical and health sciences basic medicine neurology neurodegenerative diseases parkinson
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
10142 Illkirch
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.