Objective
Lateral roots are essential to form a dense root network allowing plants to take up water and minerals effectively from the soil. Laterals are initiated from a specific organogenic cell layer within the differentiated root known as the pericycle.
The establishment and maintenance of the pericycle and the subsequent process of lateral root formation is an interesting model to study how stem-cells can be maintained within an otherwise differentiated and endoreduplicated tissue, and how these cells are re-activated into division in response to mitogenic signals.
Recently the host laboratory has investigated in detail the expression patterns of D-type cyclin (CYCD) genes in roots. Whilst several CYCD genes are expressed during the establishment and proliferation of the new pericycle cells within the primary root meristem, only two are expressed in association with the mature pericycle or during early lateral root initiation.
In particular, CYCD2;1 persists in the mature pericycle, but disappears on lateral root initiation, whereas CYCD1;1 is associated with proliferating primordial cells of lateral roots. In this project, I will investigate the hypothesis that the D-type cyclins CYCD2;1 and CYCD1;1 and their interactions with inhibitor proteins KRPs are important for maintaining the organogenic capacity of the pericycle and in the subsequent induction of lateral root induction.
The proposed model is that CYCD2;1 maintains pericycle cells in a ready-to-go state until lateral root induction is triggered by auxin. Understanding the activity and control of these proteins is therefore of central importance to integrating an understanding of cell-cycle control with plant development.
The host lab has the materials and the expertise in cell and developmental biology to carry out the proposal work and will provide both an excellent complement to the existing skills of the applicant in biochemical techniques and an international training environment.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences developmental biology
- medical and health sciences medical biotechnology cells technologies stem cells
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
CAMBRIDGE
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.