Objective
Brominated flame-retardants (BFRs) are used in a wide range of products to reduce flammability. Currently, the three main groups of chemicals used as BFRs are: polybrominated diphenylethers (PBDEs), hexabromocyclododecane (HBCD) and tetrabromobisphenol A (TBBPA).
Because of their ability of bioaccumulation and long-range transport together with possible toxic properties there is considerable concern about the effects of the main groups of BFRs still in use on humans and wildlife. Recently, high bioaccumulation of BFRs and inter-species differences in their levels were found in birds from Norway. Because of endocrine disrupting properties of the selected BFRs they can affect thyroid hormone level and the development of bird embryo and hatchling.
Understanding their mechanism of action is essential for assessing risk of BFRs to effect biodiversity and ecosystem functioning. Aim of the research is to determine between-species differences in uptake, levels, and metabolism of deca-BDE (BDE-209), HBCD and TBBPA in birds. This will be accompanied by the evaluation of thyroid disruptive effects of the chemicals on development in precocial and altricial birds.
To achieve these goals concentrations of deca-BDE (BDE-209), HBCD and TBBPA will be determine in bird species from different trophic levels and their prey items making it possible to assess uptake and bioaccumulation. Altricial and precocial species belonging to the terrestrial and marine ecosystems will be analysed. This will be followed by the examination of BFRs metabolites in the birds.
Furthermore metabolism of the BFRs compounds will be determined in-vitro and cypP450 1A and 2B activity as well as analyses of phase II enzyme activity will be done. Studies on thyroid disruptive effects will be performed on birds in controlled laboratory experiments. Thyroid hormone in plasma and TH-receptors analyses in the tissues of wild birds and laboratory ones will be conducted.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences zoology ornithology
- natural sciences biological sciences ecology ecosystems
- medical and health sciences clinical medicine embryology
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
Norway
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.