Objective
Our previous work has shown that oleic acid is a neurotrophic factor that promotes neural differentiation. In fact, oleic acid is taken up by neurons in which induce neuronal differentiation by promoting axonal growth, neuronal clustering and the expression of GAP-43 and MAP-3, markers of axonal or dendritic development, respectively.
Moreover, during the postnatal period the increase in the concentrations of free oleic acid in the brain comes along with the expression of GAP-43 and MAP-2 concurring with postnatal 'secondary neurogenesis', a phenomenon observed in ¿non precocious species¿ such as human. In this work, we try to get inside the cellular and molecular mechanisms by which oleic acid promotes neuronal differentiation in order to understand the role played by oleic acid in brain development.
This study can help to modulate the nutritional status of the newborns in order to enhance their intellectual development. In addition, our results can help also to understand a possible neuroprotector role of oleic acid against brain degeneration. If so, oleic acid may be used in the treatment of degenerative diseases such as Alzheimer or Parkinson.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- medical and health sciences basic medicine neurology neurodegenerative diseases dementia alzheimer
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine obstetrics postnatal care
- medical and health sciences basic medicine neurology neurodegenerative diseases parkinson
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-11
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
SALAMANCA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.