Objective
The infantile microbiota of Western societies is deficient in microbes that support development of tolerance to innocuous antigens, thus predisposing to allergy development. Infantile populations from non-Westernized countries need to be examined to identify protective microbial exposures for the developing immune system.
The purpose of this TOK is to build a strong method- and knowledge-based platform focussed on identifying microbes with immunoregulatory properties in the infantile gut flora and testing their mode of action ultimately aiming at rational design of probiotics with desired immunoregulatory properties. For this purpose, we will transfer methodological knowledge between the applicant and two partners in the Associated States Romania and Turkey to permit development of a common protocol for studies of infantile gut microbiota, immune development and protection from clinical allergy. In addition, the non-culture dependent technique T-RFLP will be modified and developed for assessment of infantile microbiota composition in birth-cohort studies. This involves building a data-base from known T-RFLP patterns in combination with culture and sequence data for intestinal bacteria deriving from both Westernized and non-Westernized infantile populations. Further, tools for studies of the effect of selected microbes on the immune system will be advanced and methodology for systematic testing of the immunoregulatory potential of selected microbes in humans will be established in cooperation with a probiotic SME. The project aids in defragmenting the European Research Area and increase its competitiveness by integrating researchers from EU member and Associated States, basic and clinical scientists and academic and company-driven research.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology microbiomes
- medical and health sciences basic medicine immunology
- medical and health sciences health sciences infectious diseases viral diseases RNA viruses HIV
- medical and health sciences clinical medicine allergology
- medical and health sciences basic medicine pharmacology and pharmacy
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-3
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
100 GOTEBORG
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.