Objective
Most functions and structures in living organisms seem to depend on subsets of elements organized as modules. In a modular system a certain process, performed by a module, does not depend heavily on the elements outside the module, and hence it is semi-autonomous. Modularity promotes evolvability, an organism’s capacity to generate heritable phenotypic variation, because it permits adjustment of a module without perturbing other functions and allows the combination of previously evolved functions. Understanding modularity is critical for the study of evolution and development of phenotypic traits. As several biological regulatory systems can be represented as directed networks, it would be useful to study these representations of biological systems to search for network traits that could underlie modules, and to test under which evolutionary scenarios these traits may appear. Modularity in networks has been addressed by looking for densely connected groups of nodes with sparser connections between groups. This is appropriate for undirected networks, but with directed networks a dense connectivity in a group of nodes does not suffice for semi-autonomous behavior. Feedback loops and strongly connected components (SCC) might be related to the behavior expected for a module, and thus, be considered structural signatures of modules. If this is the case, we would find more of these structures in regulatory (modular) networks than expected by chance. The first objective of this project is to test if the perceived abundance of loops and SCCs in regulatory networks is statistically significant. No study has addressed the appearance of loops and SCCs in directed networks and its relationship to modularity under realistic evolutionary scenarios. In this project several evolutionary scenarios for the evolution of modularity in directed networks will be tested, avoiding most limitations in previous attempts.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
This project has not yet been classified with EuroSciVoc.
Be the first one to suggest relevant scientific fields and help us improve our classification service
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2007-4-2-IIF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
Zürich
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.