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Structural Biology of Membrane Proteins

Structural Biology of Membrane Proteins

Objective

Membrane proteins (MPs) are known to be key molecules in cellular communications, from signal transduction to transport of ions, metabolites and other molecules. They also participate in the synthesis of ATP, the import of soluble or MPs from the cytosol, and they protect living organisms from toxic factors. The proposal consists in a joint training effort involving the major biophysical methods that are -or soon will be- the major techniques used in the field of structural biology of MPs. A collaborative effort is essential for the training of the future generation of biologists dedicated to membrane proteins. It will pave the way to an integrative approach for the study of structure-function relationships of membranes. It will therefore open new strategies for structure-based drug design, in particular toward G-protein coupled receptors (GPCR), which are major drug targets (GPCRs represent 30% of current drug targets). The training proposed in this program will not only form high-level academic researchers but will also largely contribute in forming the main actors of the future developments in biotechnology and personalized medicine. This network combines 12 academic research groups and 3 industrial companies interested in collaborating with these groups and involved in drug discovery or scientific equipment for SBMP. These groups are internationally recognized for analysing the structure and dynamics of membrane proteins by a combination of experimental and theoretical approaches: in vivo and in vitro expressions systems, functional/biochemical/biophysical characterisation, X-Ray diffraction, electron microscopy (EM), atomic force microscopy (AFM), single-molecule force spectroscopy (SMFS), liquid and solid state NMR, numerical simulations. Seven partners from 6 different countries are involved: France, Poland, Portugal, Switzerland, Germany and the Netherlands.

Coordinator

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

Address

Rue Michel Ange 3
75794 Paris

France

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 916 274

Administrative Contact

Armelle Barelli (Ms.)

Participants (11)

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INTERNATIONAL INSTITUTE OF MOLECULAR AND CELL BIOLOGY

Poland

EU Contribution

€ 246 388

INSTITUTO DE TECNOLOGIA QUIMICA E BIOLOGICA - UNIVERSIDADE NOVA DE LISBOA

Portugal

EU Contribution

€ 305 486

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE

Switzerland

EU Contribution

€ 315 989

TECHNISCHE UNIVERSITAET DRESDEN

Germany

EU Contribution

€ 145 992

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV

Germany

EU Contribution

€ 418 706

ZOBIO BV

Netherlands

EU Contribution

€ 208 657

UNIVERSITAT BASEL

Switzerland

EU Contribution

€ 563 116

JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN

Germany

EU Contribution

€ 487 014

FORSCHUNGSVERBUND BERLIN EV

Germany

EU Contribution

€ 476 090

UNIVERSITEIT UTRECHT

Netherlands

EU Contribution

€ 402 141

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH

Switzerland

EU Contribution

€ 314 147

Project information

Grant agreement ID: 211800

Status

Closed project

  • Start date

    1 September 2008

  • End date

    31 August 2012

Funded under:

FP7-PEOPLE

  • Overall budget:

    € 5 800 000

  • EU contribution

    € 5 800 000

Coordinated by:

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

France