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Structural Biology of Membrane Proteins

Objective

Membrane proteins (MPs) are known to be key molecules in cellular communications, from signal transduction to transport of ions, metabolites and other molecules. They also participate in the synthesis of ATP, the import of soluble or MPs from the cytosol, and they protect living organisms from toxic factors. The proposal consists in a joint training effort involving the major biophysical methods that are -or soon will be- the major techniques used in the field of structural biology of MPs. A collaborative effort is essential for the training of the future generation of biologists dedicated to membrane proteins. It will pave the way to an integrative approach for the study of structure-function relationships of membranes. It will therefore open new strategies for structure-based drug design, in particular toward G-protein coupled receptors (GPCR), which are major drug targets (GPCRs represent 30% of current drug targets). The training proposed in this program will not only form high-level academic researchers but will also largely contribute in forming the main actors of the future developments in biotechnology and personalized medicine. This network combines 12 academic research groups and 3 industrial companies interested in collaborating with these groups and involved in drug discovery or scientific equipment for SBMP. These groups are internationally recognized for analysing the structure and dynamics of membrane proteins by a combination of experimental and theoretical approaches: in vivo and in vitro expressions systems, functional/biochemical/biophysical characterisation, X-Ray diffraction, electron microscopy (EM), atomic force microscopy (AFM), single-molecule force spectroscopy (SMFS), liquid and solid state NMR, numerical simulations. Seven partners from 6 different countries are involved: France, Poland, Portugal, Switzerland, Germany and the Netherlands.

Field of science

  • /natural sciences/chemical sciences/analytical chemistry/spectroscopy
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins
  • /natural sciences/biological sciences/molecular biology/structural biology
  • /social sciences/social and economic geography/transport

Call for proposal

FP7-PEOPLE-2007-1-1-ITN
See other projects for this call

Funding Scheme

MC-ITN - Networks for Initial Training (ITN)

Coordinator

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Address
Rue Michel Ange 3
75794 Paris
France
Activity type
Research Organisations
EU contribution
€ 1 916 274
Administrative Contact
Armelle Barelli (Ms.)

Participants (11)

INTERNATIONAL INSTITUTE OF MOLECULAR AND CELL BIOLOGY
Poland
EU contribution
€ 246 388
Address
Ks. Trojdena 4
02-109 Warsaw
Activity type
Research Organisations
Administrative Contact
Urszula Wyrzykowska (Dr.)
INSTITUTO DE TECNOLOGIA QUIMICA E BIOLOGICA - UNIVERSIDADE NOVA DE LISBOA
Portugal
EU contribution
€ 305 486
Address
Avenida Da Republica, Estacao Agronomica Nacional
2784-505 Oeiras
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Margarida Martinez (Ms.)
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland
EU contribution
€ 315 989
Address
Batiment Ce 3316 Station 1
1015 Lausanne
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Horst Vogel (Prof.)
TECHNISCHE UNIVERSITAET DRESDEN

Participation ended

Germany
EU contribution
€ 145 992
Address
Helmholtzstrasse 10
01069 Dresden
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Claudia Hawke (Ms.)
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany
EU contribution
€ 418 706
Address
Hofgartenstrasse 8
80539 Munich
Activity type
Other
Administrative Contact
Manfred Messerschmidt (Mr.)
ZOBIO BV
Netherlands
EU contribution
€ 208 657
Address
J.h. Oortweg 19
2333 CH Leiden
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Robert Heetebrij (Mr.)
UNIVERSITAT BASEL
Switzerland
EU contribution
€ 563 116
Address
Petersplatz 1
4051 Basel
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eva Kramer
JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN
Germany
EU contribution
€ 487 014
Address
Theodor W Adorno Platz 1
60323 Frankfurt Am Main
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Christoph Denecke (Mr.)
FORSCHUNGSVERBUND BERLIN EV
Germany
EU contribution
€ 476 090
Address
Rudower Chaussee 17
12489 Berlin
Activity type
Research Organisations
Administrative Contact
Anne Hoener (Dr.)
UNIVERSITEIT UTRECHT
Netherlands
EU contribution
€ 402 141
Address
Heidelberglaan 8
3584 CS Utrecht
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Liesbeth Bos-Klomp (Ms.)
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland
EU contribution
€ 314 147
Address
Raemistrasse 101
8092 Zuerich
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Daniel Mueller (Prof.)