Objective
Our aim is to find new antibacterial molecules with novel mechanisms of action, by applying new and innovative approaches in organic and medicinal chemistry, such as diversity-oriented synthesis (DOS) and chemical genetics. The concrete objectives are: -Development of diversity-oriented synthesis (DOS) using solid phase and solution synthesis to obtain collections of highly diverse and complex small cyclic peptide derivatives including small cyclic di- tri- and tetra- peptides as well as bicyclic diketopiperazines (DKP's). -Development of new methodologies for solid phase organic synthesis: optimization of relatively new reactions such as RCM or enyne metathesis on solid phase. -Biological screening of the molecular libraries on cultures of human pathogen bacteria and selection of the most active compounds to identify new modes of antibacterial action. This project addresses major challenges in both therapeutics and organic synthesis, such as bacterial resistance to existing drugs, development of new methodologies for solid phase organic synthesis and diversity-oriented synthesis and chemical genetics in Europe. It is a multidisciplinary project that involves a highly valuable education for the candidate in new scientific aspects related to his research field.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics
- natural sciences biological sciences microbiology bacteriology
- medical and health sciences basic medicine medicinal chemistry
- natural sciences biological sciences biochemistry biomolecules
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs antibiotics
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-IEF-2008
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
CB2 1TN CAMBRIDGE
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.