Objective
Src-family kinases play major roles in promoting adherens junctions remodelling in development and metastasis. Their activities are negatively regulated by C-terminal Src kinase (Csk). The host lab it has recently shown that Drosophila Ankyrin-repeat, SH3-domain and Proline-rich-region containing (dASPP), together with Boa the homology of mammalian Ras association domain family 8, regulates the function of dCsk in maintaining adherens junctions polarity and integrity in Drosophila (Langton et al., 2007 and unpublished data). However, the molecular nature of this interaction and the exact functions of dASPP and Boa on developing epithelia are still unknown. In this research project, we propose to address the molecular mechanism by which dASPP and Boa regulates dCsk activity and their function in epithelial growth and morphogenesis during development, as well as identify new regulators of Src signalling in epithelial cells.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-IEF-2008
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
E20 1JQ LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.