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Content archived on 2024-05-30

Biologically Active Organic Compounds Interacting with Adenine-binding Proteins

Objective

Proposed are rational design and synthesis of novel patentable organic compounds that are envisioned to be active against various adenine-binding proteins, e.g. kinases. The structures contain heterocyclic cores relatively unknown in the literature and will mimic interations of purine-containing biological substrates (especially ATP) with proteins that are relevant in oncology. The compounds will be synthesized by modern methods of organic synthesis, namely by ring-closing olefin metathesis and will be profiled in biological assays that include diverse biological targets, especially those that are related to the treatment of cancer.

Fields of science (EuroSciVoc)

Topic(s)

Call for proposal

FP7-PEOPLE-IRG-2008
See other projects for this call

Funding Scheme

MC-IRG - International Re-integration Grants (IRG)

Coordinator

Masarykova univerzita
EU contribution
€ 100 000,00
Address
Zerotinovo namesti 9
601 77 Brno
Czechia
Region
Česko Jihovýchod Jihomoravský kraj
Activity type
Higher or Secondary Education Establishments
Links
Total cost
No data