Objective
Homotopic areas of primary motor cortices of both hemispheres are tightly interconnected and show both inhibitory and excitatory interactions, which are delicately balanced in healthy subjects. In disease this balance can be lost or impaired. Accordingly, some movement disorders occur lateralised. In early Parkinson’s Disease (PD) symptoms begin unilaterally, although unilateral changes on the cortical level are lacking. In focal task-induced hand dystonia (FHD) symptoms solely occur on one side and only spread in a minority of patients also to the other side. However, the pathophysiological role of interhemispheric interaction between both primary motor cortices in PD and FHD and its influence on cerebro-muscular coupling and cerebral oscillatory networks subserving motor activity is not finally understood yet. Repetitive transcranial magnetic stimulation (rTMS) allows to modulate human brain activity. Using this feature it becomes possible to explore the characteristics of physiological and pathological cerebral networks and to modify these temporarily. Magnetoencephalography (MEG) enables us to characterise oscillatory synchronisation in the human brain. Moreover, MEG offers the possibility to scrutinise cerebro-muscular and cerebro-cerebral couplings. This allows to describe broad cerebral oscillatory networks including interhemispheric coupling. Combining rTMS and MEG the proposed project aims to reveal, how rTMS acts on the interhemispheric interaction in patients suffering from both PD and FHD and healthy subjects. Moreover, changes of oscillatory synchronisation induced by rTMS, i.e. resting state brain activity, cerebral oscillatory networks and cerebro-muscular coupling, will be characterised. Hence, results have the potential to enhance our understanding of the role of interhemispheric interaction in physiology and disease and to characterise the impact of disturbance of this interaction in PD and FHD.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine physiology
- medical and health sciences basic medicine neurology neurodegenerative diseases parkinson
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2009-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
WC1E 6BT LONDON
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.