Objective
Cellular concentrations of transition metals are tightly regulated to a necessary balance to satisfy essential requirements for the activity of fundamental biochemical processes and avoid toxic levels which would impair cell survival. P1B-type ATPases are a family of membrane ion pumps which utilize the energy generated by ATP hydrolysis to drive the selective heavy metal translocation across the cellular membrane against the electrochemical gradient. Although playing a pivotal role in regulating the concentrations of essential physiological metal elements (e.g: Cu, Zn) and toxic transition metals (e.g.: Cd, Pb), the mechanism by which these molecular machines perform their function are not understood in detail. The proposed project aims to reveal at a molecular level the principles and determinants for heavy metal selectivity, metal binding geometry, metal translocation pathway, and energy transduction processes in energy-driven metal transport in P1B-type ATPases. A complementary X-ray crystallographic and biochemical approach will be developed in order to obtain a molecular understanding of the three-dimensional structure and the function of prokaryotic P1B-type ATPases. The final goal is to reveal how these molecular machines convert the energy stored in ATP into conformational changes which result into directional transport of heavy metal across the lipid bilayer. Elucidating the mechanism of transition metal transport across biological membranes accomplished by P1B-type ATPases will shed light on an essential biochemical process conserved in all the kingdoms of life and will provide the bases for the future rational design of modulators of P1B-type ATPase activity.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules lipids
- natural sciences mathematics pure mathematics geometry
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2009-IOF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
8000 Aarhus C
Denmark
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.