Objective
This proposal is focused on the development of a meat-based functional food (pâté, sausage, snacks etc.) able to effectively reduce cholesterol levels in serum by acting simultaneously at two different levels: (I) reducing endogenous cholesterol synthesis by inhibiting the hydroxymethylglutaryl-CoA reductase (the key enzyme in the cholesterol metabolism) and (II) impairing exogenous cholesterol absorption during digestion by its displacement from the dietary mixed micelles and binding of bile acids during the intestinal digestion to avoid their reabsorption. Edible mushrooms will be submitted to accelerate solvent extraction (ASE) and supercritical fluid extraction (SFE) to obtain (T1) polysaccharides (b-glucans), (T2) statin-like or other metabolites and (T3) ergosterol-derivatives concentrates. These concentrates and their mixtures (T1+T2+T3 in a meat-based food matrix) will be screened for their properties to act as (I) and (II). All samples will be submitted to in vitro digestion and absorption tests (using Caco2 cell models) to study their bioavailability and molecular mechanism of action. Responsible compounds will be identified and quantified by analytical standardized tools (HPLC-, GC-MS etc)
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules carbohydrates
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2009-IIF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
28049 Madrid
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.