Objective
Plant in vitro technologies have been known for more than century. During this time, plant cell, tissue and organ cultures have become increasingly attractive and cost-effective alternatives to classical approaches for the mass production of plant metabolites. Furthermore, plant in vitro systems are the only economically feasible way of producing some high-value metabolites from rare and/or threatened plants. The progress in this field has resulted in the mass production of several important metabolites, such as taxol (paclitaxel), shikonin and berberine by different companies. However, for their production several problems had to be overcome, mainly connected with their cultivation in vitro and high sensitivity to different stress factors/conditions. Today in the postgenomic era, new functional genomic tools (transcriptomics and proteomics), enabling comprehensive investigations of biological systems, are continuously further developing and are gradually being implemented in the field of plant secondary metabolism. The latest of the “omics” is metabolomics, which is now combined with the other “omics” and such a holistic functional genomic approach forms systems biology, in which the synergism of this powerful combination opens novel avenues to fully explore the total biochemical machinery of plants. The general objective of the scientific project is to evaluate the systems biology based approach for bioproduction of pharmaceutically important iridoids from difficult-to-access and endemic Bulgarian plant species. This includes transcriptomic analyses, metabolomics and assessment of biological activities. The metabolic engineering aspects will be also covered through gene/multigene transformations. The project will finally seek for development of technology platform for iridoids production in the green cell factory.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology industrial biotechnology metabolic engineering
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2009-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
2311 EZ Leiden
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.