Objective
Invariant natural killer T (iNKT) cells play crucial roles in protection against cancer in murine models. We have described large populations of iNKT cells in the human omentum, which until now were thought to be rare in humans. Omental iNKT cells display potent cytotoxicity against autologous tumors in vitro however, in patients with obesity and cancer, iNKT cells are depleted. This fellowship seeks to answer many questions which have remained elusive since the discovery of iNKT cells 15 years ago, such as what is their physiological role in humans, why do they accumulate in fat, and what is the natural lipid ligand for these cells. We will study omental iNKT cells and omental lipids in human and murine fat and investigate their role in obesity and cancer using in vivo and in vitro techniques, interventional studies and genetically defined specific gene-deleted animals. In addition, I hypothesise a completely novel function for iNKT cells in the prevention of obesity related chronic inflammation and metabolic disorders. Our research may lead to the discovery of novel immunotherapeutics for the treatment of malignancy and certain obesity-related complications.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules lipids
- medical and health sciences clinical medicine oncology
- medical and health sciences health sciences nutrition obesity
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2009-IOF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
D02 CX56 Dublin
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.