Objective The strategic development of accurate biomarkers to predict response to therapy in cancer medicine will enhance clinical outcome and reduce the health economic impact of drug resistant disease. The PREDICT consortium will identify and validate predictive biomarkers for two drugs which have direct anti-tumour cell and anti-angiogenic activity and for which no established predictive biomarkers of tumour response exist: sunitinib, a multi-targeted tyrosine kinase inhibitor, and everolimus, an mTOR pathway inhibitor. Renal cell carcinoma (RCC), a disease sensitive to these agents, will serve as the model tumour type to identify predictive response biomarkers suitable for widespread application across diverse tumour types. PREDICT’s biomarker discovery approach is based on the integration of genomics data from pre-operative RCC therapeutic clinical trials with novel personalised functional genomic screen datasets. We will systematically collect tumour tissue from monotherapy pre-operative window RCC clinical trials of 240 patients treated with everolimus or sunitinib and determine expression profiles, copy number aberrations, and genome-wide exon sequences of tumours before and after drug treatment. We will perform two types of RNA interference drug- and hypoxia-resistance screens: one using reverse transfection of commercial siRNA libraries into previously established RCC cell lines, and one using a novel approach through personalised tumour cDNA derived-shRNA library transduction of ex-vivo cultured autologous tumour cell lines. Bioinformatics integration of these complementary individualised clinical and experimental datasets will enable the rapid and cost efficient identification of predictive biomarkers and simultaneously define molecular mechanisms contributing to intrinsic and acquired drug resistant disease in vivo, yielding additional targets for therapeutic intervention. Fields of science medical and health sciencesclinical medicineoncologynatural sciencesbiological sciencesgeneticsRNA Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2010.2.4.1-8 - Predicting individual response and resistance to cancer therapy. FP7-HEALTH-2010-two-stage Call for proposal FP7-HEALTH-2010-two-stage See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator DANMARKS TEKNISKE UNIVERSITET EU contribution € 762 240,00 Address ANKER ENGELUNDS VEJ 101 2800 Kongens Lyngby Denmark See on map Region Danmark Hovedstaden Københavns omegn Activity type Higher or Secondary Education Establishments Administrative Contact Marlene Beck (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (13) Sort alphabetically Sort by EU Contribution Expand all Collapse all CANCER RESEARCH UK LBG United Kingdom EU contribution € 1 483 296,00 Address 2 Redman Place E20 1JQ LONDON See on map Region London Inner London — West Camden and City of London Activity type Research Organisations Administrative Contact Louisa Jacobs (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data GENOME RESEARCH LIMITED United Kingdom EU contribution € 517 497,60 Address WELLCOME SANGER INSTITUTE WELLCOME GENOME CAMPUS HINXTON CB10 1SA SAFFRON WALDEN See on map Region East of England East Anglia Cambridgeshire CC Activity type Research Organisations Administrative Contact Angela Macharia (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE ROYAL MARSDEN NATIONAL HEALTH SERVICE TRUST United Kingdom EU contribution € 688 500,00 Address Fulham Road 203-6 SW3 6JJ London See on map Region London Inner London — West Kensington & Chelsea and Hammersmith & Fulham Activity type Research Organisations Administrative Contact James Larkin (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data INSTITUT GUSTAVE ROUSSY France EU contribution € 376 440,00 Address Rue Camille Desmoulins 39 94805 Villejuif See on map Region Ile-de-France Ile-de-France Val-de-Marne Activity type Research Organisations Administrative Contact Arnauld Forest (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data SEMMELWEIS EGYETEM Hungary EU contribution € 322 633,60 Address ULLOI UTCA 26 1085 Budapest See on map Region Közép-Magyarország Budapest Budapest Activity type Higher or Secondary Education Establishments Administrative Contact Balazs Gyorffy (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data NATURWISSENSCHAFTLICHES UND MEDIZINISCHES INSTITUT AN DER UNIVERSITAET TUEBINGEN Germany EU contribution € 516 702,00 Address MARKWIESENSTRASSE 55 72770 Reutlingen See on map Region Baden-Württemberg Tübingen Reutlingen Activity type Research Organisations Administrative Contact Thomas Schweikert (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data EXPERIMENTELLE PHARMAKOLOGIE UND ONKOLOGIE BERLIN-BUCH GMBH Germany EU contribution € 284 250,00 Address ROBERT-ROESSLE-STRASSE 10 13125 Berlin See on map Region Berlin Berlin Berlin Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Jens Hoffmann (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Horizon Discovery Limited United Kingdom EU contribution € 171 750,00 Address CAMBRIDGE RESEARCH PARK CB25 9TL Cambridge See on map Region East of England East Anglia Cambridgeshire CC Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Torrance Christopher (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Bayer Pharma AG Germany EU contribution € 328 700,00 Address Muellerstrasse 178 13353 Berlin See on map Region Berlin Berlin Berlin Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Hans-Dieter Pohlenz (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ASSISTANCE PUBLIQUE HOPITAUX DE PARIS France EU contribution € 46 055,20 Address 55 BOULEVARD DIDEROT 75012 Paris See on map Region Ile-de-France Ile-de-France Val-de-Marne Activity type Research Organisations Administrative Contact Christophe Misse (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ASSOCIATION POUR LA RECHERCHE DE THERAPEUTIQUES INNOVANTES EN CANCEROLOGIE France EU contribution € 330 944,80 Address RUE DES BRUYERES 47 94370 SUCY EN BRIE See on map Activity type Research Organisations Administrative Contact Reza Elaidi (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data QUEEN MARY UNIVERSITY OF LONDON United Kingdom EU contribution € 6 000,00 Address 327 MILE END ROAD E1 4NS London See on map Region London Inner London — East Tower Hamlets Activity type Higher or Secondary Education Establishments Administrative Contact Thomas Powles (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS Netherlands EU contribution € 6 000,00 Address PLESMANLAAN 121 1066 CX Amsterdam See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Research Organisations Administrative Contact Henri G.A.M. Van Luenen (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data