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International Human Microbiome Standards

International Human Microbiome Standards

Objective

A detailed understanding of human biology will require characterisation of the human-associated microorganisms, the human microbiome, and of the roles these microbes play in health and disease. Large projects in Europe, the United States, China and Canada target these objectives, using high throughput –omics approaches. Given the complexity of our microbial communities, composed of thousands of species and differing considerably between individuals, as well as the multitude of effects they have on our biology, none of the projects can hope to achieve their comprehensive characterisation. To progress most efficiently towards this ambitious goal it is of utmost importance that the data generated in each individual project be optimally comparable across all the current projects and those yet to come. Our proposal seeks to coordinate development of standard operating procedures and protocols, which will optimize data comparisons in the human microbiome field and thus improve the synergy between all the projects. It focuses on three key aspects of data generation: (i) human sample collection, processing and identification via the associated metadata; (ii) DNA sequence quality obtained by the new generation methods from complex microbial mixtures; (iii) analysis of DNA sequence in conjunction with the metadata. Importantly, it organises public access to the standard operating procedures and protocols and enables exchanges between the users and providers of the standards. It gathers very strong international partnership that includes leaders in the field and represents the current large projects, which span three continents, Europe, Asia and America. Furthermore, it interfaces via the International Human Microbiome Consortium with additional projects from Africa and Australia. The proposal is thus highly congruent with the focus of the call, which targets omics, standards and international context.
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Coordinator

INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE

Address

Rue De L'Universite 147
75338 Paris Cedex 07

France

Activity type

Research Organisations

EU Contribution

€ 759 626

Administrative Contact

Florence Haimet (Ms.)

Participants (7)

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INSTITUT CATALA DE LA SALUT

Spain

EU Contribution

€ 99 964

BAYLOR COLLEGE OF MEDICINE

United States

EU Contribution

€ 110 000

SHANGHAI JIAO TONG UNIVERSITY

China

EU Contribution

€ 60 027

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

France

EU Contribution

€ 299 020

Beijing Genomics Institute at Shenzhen

China

EU Contribution

€ 149 907

EUROPEAN MOLECULAR BIOLOGY LABORATORY

Germany

EU Contribution

€ 490 340,06

THE UNIVERSITY OF WESTERN ONTARIO

Canada

EU Contribution

€ 30 002

Project information

Grant agreement ID: 261376

Status

Closed project

  • Start date

    1 February 2011

  • End date

    31 January 2015

Funded under:

FP7-HEALTH

  • Overall budget:

    € 2 289 894,51

  • EU contribution

    € 1 998 886,06

Coordinated by:

INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE

France