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European West Nile collaborative research project

Objective

West Nile virus (WNV) is one of the most evident examples of emerging/re-emerging pathogens one can nominate, which is characterized by occasional virulent epizootic outbreaks. Despite intensive research done since its first appearance in the Americas in 1999, many aspects of its molecular biology, epidemiology, ecology, pathogenesis and life cycle are still poorly understood. Being a generalist pathogen par excellence, its eco-epidemiology is extraordinarily complex, involving hundreds of different vectors and hosts, which differ between locations. In addition, as other RNA viruses lacking proofreading replication, its genome is highly variable and consequently of extraordinary plasticity. As a result, many WNV variants have evolved independently in different parts of the world. As the virus moves from one area to another, either by nature, through migrating birds, or by human influence (commerce and/or other activities), different WNV variants (lineages) from different origins can coexist and co-evolve in a particular area. This is the case in Europe, with at least five of seven WNV lineages identified to date. This situation is clearly different from that of North America. However, most studies on WNV currently come from the USA, biasing the knowledge available not only toward the virus there -a serious bias with important consequences influencing, for instance, diagnostic methods- but also to the WNV ecology in hosts and vectors.
In the present Project we propose to conduct comprehensive studies on the WNV situation in Europe and affected surrounding countries that accounting for the peculiarities of WNV eco-epidemiology in this region. Moreover we will strive to cover knowledge gaps regarding its ecology, epidemiology and pathogenesis in Europe. Finally, the Project aims to develop new tools and strategies for research on treatment and prevention of WNV disease, as well as to produce new diagnostic methods, taking Euro-Mediterranean peculiarities into account

Call for proposal

FP7-HEALTH-2010-single-stage
See other projects for this call

Coordinator

INSTITUTO DE SALUD CARLOS III
Address
Monforte De Lemos 5
28029 Madrid
Spain
Activity type
Research Organisations
EU contribution
€ 445 175,20
Administrative Contact
Antonio Tenorio (Dr.)

Participants (15)

VETERINAERMEDIZINISCHE UNIVERSITAET WIEN
Austria
EU contribution
€ 250 980
Address
Veterinaerplatz 1
1210 Vienna
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Barbara Greineder (Ms.)
AGENCE NATIONALE DE LA SECURITE SANITAIRE DE L ALIMENTATION DE L ENVIRONNEMENT ET DU TRAVAIL
France
EU contribution
€ 154 494
Address
14 Rue Pierre Et Marie Curie
94700 Maisons Alfort
Activity type
Research Organisations
Administrative Contact
Sylvie Lecollinet (Dr.)
INSTITUT PASTEUR
France
EU contribution
€ 229 177,20
Address
Rue Du Docteur Roux 25-28
75724 Paris Cedex 15
Activity type
Research Organisations
Administrative Contact
Nathalie Pardigon (Dr.)
MEDICAL RESEARCH AND DEVELOPMENT FUND FOR HEALTH SERVICES
Israel
EU contribution
€ 127 332
Address
Ben-tabai St 2
52601 Ramat-gan/israel
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Gabi Bin Nun (Mr.)
ISTITUTO ZOOPROFILATTICO SPERIMENTALE DELLA LOMBARDIA E DELL'EMILIA ROMAGNA BRUNO UBERTINI
Italy
EU contribution
€ 220 897
Address
Via Antonio Bianchi 9
25124 Brescia
Activity type
Research Organisations
Administrative Contact
Lauretta Cocchi (Dr.)
ISTITUTO SUPERIORE DI SANITA
Italy
EU contribution
€ 236 706
Address
Viale Regina Elena 299
00161 Roma
Activity type
Research Organisations
Administrative Contact
Rosa Maria Martoccia (Dr.)
FONDAZIONE EDMUND MACH
Italy
EU contribution
€ 218 081
Address
Via Edmondo Mach 1
38010 San Michele All'adige
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Roberto Viola (Dr.)
CENTRAL RESEARCH INSTITUTE OF EPIDEMIOLOY
Russia
EU contribution
€ 119 460
Address
Novogireevskaya 3A
111123 Moscow
Activity type
Research Organisations
Administrative Contact
Alexander Platonov (Prof.)
INSTITUT PASTEUR DE DAKAR
Senegal
EU contribution
€ 95 670
Address
Avenue Pasteur 36
DAKAR Dakar
Activity type
Research Organisations
Administrative Contact
Amadou A Sall (Dr.)
INSTITUTO NACIONAL DE INVESTIGACION Y TECNOLOGIA AGRARIA Y ALIMENTARIA OA MP
Spain
EU contribution
€ 257 482,80
Address
Carretera De La Coruna Km7.5
28040 Madrid
Activity type
Research Organisations
Administrative Contact
María Alarcon Alarcon (Ms.)
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
EU contribution
€ 258 521
Address
Calle Serrano 117
28006 Madrid
Activity type
Research Organisations
Administrative Contact
Eusebio Jimenez Arroyo (Mr.)
VIRCELL SL
Spain
EU contribution
€ 194 797,80
Address
P.i Dos De Octubre Pza Dominguez Ortiz 1
18320 Santa Fe Granada
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Arantxa Cortés (Dr.)
INMUNOLOGIA Y GENETICA APLICADA SA
Spain
EU contribution
€ 190 299
Address
C/ Hermanos Garcia Noblejas 41-2
28037 Madrid
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Eduardo Dominguez (Mr.)
ISTITUTO ZOOPROFILATTICO SPERIMENTALE DELLE VENEZIE
Italy
Address
Viale Dell Universita 10
35020 Legnaro
Activity type
Other
Administrative Contact
Alessandro Bertoldi (Dr.)
USTAV BIOLOGIE OBRATLOVCU AV CR, V.V.I.
Czechia
Address
Kvetna 8
CZ-60365 Brno
Activity type
Research Organisations
Administrative Contact
Pavla Bartova