Objective
Targeted delivery of therapeutic compounds to selective cell types is of great clinical importance and can minimize undesired side effects. Recently, we have introduced a way to target the delivery of sodium channel blockers selectively to nociceptive neurons, and thus capitalize on their effectiveness in blocking action potentials but now only at sites of pain generation. Using this approach we have been able to abolish the response to noxious mechanical and thermal stimuli without motor or tactile deficit (Binshtok et al., Nature). This approach represents a novel concept of targeted delivery and can be used to block activity and also to modulate intracellular signal transduction and metabolism pathways in pain- sensing neurons a well as cancer or any other large cation non-selective channels-expressing cells, while minimizing effects on other types of cells. We now need further explore the utility of this technique for clinical use as an analgesic and also see if the strategy can be used in more generalized way to targeted delivery of charger compounds, beyond charged local anesthetics, to specific types of cells.
This project aims to develop methods for targeted delivery of charged local anesthetics to diminish inflammatory, postoperative and neuropathic pain. The second part of this project will be to examine different strategies to expand the approach to selectively target charged cytotoxic or antiproliferative compounds into cancer cells. This interdisciplinary project will incorporate imaging techniques and electrophysiological, histological and behavioral experiments. We believe that the results of our work will lead to a more effective treatment of pain with significantly fewer side effects. Furthermore targeted delivery of chemotherapeutic agents into tumor cell will improve their therapeutic index and hereby limits their side effects as well as the associated pain.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences inorganic chemistry alkali metals
- medical and health sciences clinical medicine oncology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2010-RG
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
91904 Jerusalem
Israel
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.